Cyclic change of cytokines in a patient with cyclic thrombocytopenia

Fumihiko Kimura, Yukistugu Nakamura, Ken Sato, Naoki Wakimoto, Takashi Kato, Tomoyuki Tahara, Muneo Yamada, Naokazu Nagata, Kazuo Motoyoshi*

*この研究の対応する著者

研究成果: Article査読

29 被引用数 (Scopus)

抄録

The serial change of various cytokines in the serum from a patient with cyclic thrombocytopenia is described, Interleukin 7, stem cell factor, and transforming growth factor β1 synchronized with the platelet count, and there was a significant positive correlation between the three cytokines and the platelet count. Levels of macrophage colony-stimulating factor, thrombopoietin, platelet-associated IgG and erythropoietin changed reciprocally with the platelet count, and there was a significant negative correlation between the platelet count and these cytokines except erythropoietin. No cyclic change was observed in IL-3, IL-6, IL-11, granulocyte-macrophage colony-stimulating factor, or leukaemia inhibitory factor. These observations suggest that this disease involves two cyclic changes: megakaryocytopoiesis and platelet destruction, in both of which the cytokines play an important role.

本文言語English
ページ(範囲)171-174
ページ数4
ジャーナルBritish Journal of Haematology
94
1
DOI
出版ステータスPublished - 1996
外部発表はい

ASJC Scopus subject areas

  • 血液学

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