Cyclotheonamides E2 and E3, new potent serine protease inhibitors from the marine sponge of the genus Theonella

Y. Nakao, N. Oku, S. Matsunaga, N. Fusetani*

*この研究の対応する著者

研究成果: Article査読

51 被引用数 (Scopus)

抄録

Two new potent serine protease inhibitors, cyclotheonamides E2 (3) and E3 (4), have been isolated from a marine sponge of the genus Theonella. Their structures were determined by interpretation of spectral data and chemical degradation studies. They are closely related to the previously reported cyclotheonamide E, from which they differ in the N-acyl group of the alanyl side chain. Cyclotheonamides E, E2, and E3 were more active against thrombin than against trypsin.

本文言語English
ページ(範囲)667-670
ページ数4
ジャーナルJournal of Natural Products
61
5
DOI
出版ステータスPublished - 1998 6月 18
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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