Dearomative Allylation of Naphthyl Cyanohydrins by Palladium Catalysis: Catalyst-Enhanced Site Selectivity

Aika Yanagimoto, Masaaki Komatsuda, Kei Muto, Junichiro Yamaguchi

研究成果: Article査読

3 被引用数 (Scopus)

抄録

A dearomative allylation of naphthyl cyanohydrins with allyl borates and allyl stannanes under palladium catalysis was developed. At the initial stage of this study, the dearomative reaction (C4 substitution of the aromatics) was competing with benzyl substitution. To circumvent this issue, the use of palladium and meta-disubstituted triarylphosphine as the catalyst in a 1:1 ratio was found to enhance the site selectivity, furnishing the desired dearomatized products. Further derivatizations of products were also successful.

本文言語English
ページ(範囲)3423-3427
ページ数5
ジャーナルOrganic Letters
22
9
DOI
出版ステータスPublished - 2020 5 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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