Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis

Ryosuke Takise, Ryota Isshiki, Kei Muto, Kenichiro Itami*, Junichiro Yamaguchi

*この研究の対応する著者

研究成果: Article査読

97 被引用数 (Scopus)

抄録

Because diaryl ethers are present as an important motif in pharmaceuticals and natural products, extensive studies for the development of novel methods have been conducted. A conventional method for the construction of the diaryl ether moiety is the intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst. We developed a catalytic decarbonylative etherification of aromatic esters using a palladium or nickel catalyst with our enabling diphosphine ligand to give the corresponding diaryl ethers. The present reaction can be conducted on gram scale in excellent yield. This reaction not only functions in an intramolecular setting but also allows for a cross-etherification using other phenols.

本文言語English
ページ(範囲)3340-3343
ページ数4
ジャーナルJournal of the American Chemical Society
139
9
DOI
出版ステータスPublished - 2017 3月 8

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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