Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

Yoshihiro Watanabe, Takuya Suga, Satomi Narusawa, Masato Iwatsuki, Kenichi Nonaka, Takuji Nakashima, Yasuo Shinohara, Takahiro Shiotsuki, Naoya Ichimaru, Hideto Miyoshi, Yukihiro Asami, Satoshi Omura, Kazuro Shiomi*

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ∼50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.

本文言語English
ページ(範囲)395-399
ページ数5
ジャーナルJournal of Antibiotics
70
4
DOI
出版ステータスPublished - 2017 4 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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