Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi, Takao Shimazoe*, Seiko Nagata, Takahiro Moriya, Miyuki Maetani, Shigenobu Shibata, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

*この研究の対応する著者

研究成果: Article査読

18 被引用数 (Scopus)

抄録

We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

本文言語English
ページ(範囲)103-106
ページ数4
ジャーナルNeuroscience Letters
227
2
DOI
出版ステータスPublished - 1997 5月 16

ASJC Scopus subject areas

  • 神経科学(全般)

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