Defective phospholipid metabolism in the retinular cell membrane of norpA (no receptor potential) visual transduction mutants of Drosophila

Tohru Yoshioka*, Hiroko Inoue, Yoshiki Hotta

*この研究の対応する著者

研究成果: Article査読

37 被引用数 (Scopus)

抄録

The phosphorylation of photoreceptor phospholipids in the three alleles of Drosophila visual mutants (norpA : no receptor potential A gene) was studied. In the normal strain, the γ-32P of ATP was transferred mainly to phosphatidic acid (PA) and diphosphoinositide (DPI), while, in the mutants, we found that the phosphorylation of PA was drastically reduced, but that of DPI was not. The radioactivity incorporation into PA closely parallels with the degree of the mutant genes' expressivity among the three alleles of norpA tested. Therefore, the abnormality found in the phosphorylation of diglycerol to PA may be closely related to the primary mutant defect in the phototransduction mechanism.

本文言語English
ページ(範囲)567-573
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
111
2
DOI
出版ステータスPublished - 1983 3 16
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 生物理学
  • 分子生物学

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