Design a novel asymmetric bifurcating microfluidic channel for cell separation by size

Zhonggang Feng, Takao Nakamura, Daisuke Sato, Tatsuo Kitajima, Mitsuo Umezu

研究成果: Conference contribution

抄録

In this paper, we exhibit a novel asymmetric bifurcating microchannel for cell separation by size. As developing this microchannel, we proposed the design and optimization criteria, which included the design of inlet and outlet based on the analysis of the Segre-Silberberg effect and the optimization principle to render the migration force at the bifurcation portion as great as possible. Experiments using rat fibroblasts and red blood cells verified these design principles and confirmed the separation function with the optimal design. The simple configuration of the microchannel makes it feasible to serialize several such microchannels within 1.0×1.0 mm2 space and to achieve enrichment rate as high as 103∼104 folds.

本文言語English
ホスト出版物のタイトル2015 10th Asian Control Conference
ホスト出版物のサブタイトルEmerging Control Techniques for a Sustainable World, ASCC 2015
編集者Hazlina Selamat, Hafiz Rashidi Haruna Ramli, Ahmad Athif Mohd Faudzi, Ribhan Zafira Abdul Rahman, Asnor Juraiza Ishak, Azura Che Soh, Siti Anom Ahmad
出版社Institute of Electrical and Electronics Engineers Inc.
ISBN(電子版)9781479978625
DOI
出版ステータスPublished - 2015 9 8
イベント10th Asian Control Conference, ASCC 2015 - Kota Kinabalu, Malaysia
継続期間: 2015 5 312015 6 3

出版物シリーズ

名前2015 10th Asian Control Conference: Emerging Control Techniques for a Sustainable World, ASCC 2015

Other

Other10th Asian Control Conference, ASCC 2015
CountryMalaysia
CityKota Kinabalu
Period15/5/3115/6/3

ASJC Scopus subject areas

  • Control and Systems Engineering

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