Design and performance from an integrated PET/MRI system for small animals

Seiichi Yamamoto*, Masao Imaizumi, Yasukazu Kanai, Mitsuaki Tatsumi, Masaaki Aoki, Eiji Sugiyama, Makoto Kawakami, Eku Shimosegawa, Jun Hatazawa

*この研究の対応する著者

研究成果: Article査読

78 被引用数 (Scopus)

抄録

Objective Although simultaneous measurements of PET and magnetic resonance imaging (MRI) can provide interesting results in molecular imaging research, most of the combined systems are huge and animal handling in the system is not easy. To minimize these problems, we developed a compact integrated PET/MRI (iPET/MRI) system for small animals. Methods For the iPET/MRI system, a new MR-compatible PET and a permanent magnet open MRI were designed. In the MRI, a tunnel is opened at the yoke of the magnet. The position-sensitive photo-multiplier tubes (PSPMTs) of the MR-compatible PET are positioned at the back of the yoke where the magnetic field is sufficiently low. The scintillators for the PET system are positioned at the center of the MRI magnets, and the direction of the scintillation photons is changed by slanted light guides, and they are fed to the PSPMTs by 75 cm long optical fiber bundles. The PET detectors employed two types of LGSO crystals (1.9 mm×9 2.2 mm×6 mm and 7 mm) with different decay times (33 and 43 ns) for depth of interaction detection. Sixteen optical fiber-based block detectors are arranged in a 112 mm diameter ring. Results The transaxial field-of-view (FOV) of the PET system is ∼80 mm, and the axial FOV is 21 mm which can be enlarged by the axial motion of the PET detector ring during MRI acquisition. The transaxial and axial resolutions at the center of the PET system was 2.9 and 2.4 mm FWHM, respectively. The absolute sensitivity was 1.5% at the center of the axial FOV. Phantom images revealed no artifact in either the PET or MRI images. We successfully obtained simultaneously measured small animal images using the iPET/MRI system. Conclusion The open geometry of the developed iPET/ MRI facilitates easy accessibility to the subject. The iPET/ MRI system appears to be a promising tool for molecular imaging research.

本文言語English
ページ(範囲)89-98
ページ数10
ジャーナルAnnals of Nuclear Medicine
24
2
DOI
出版ステータスPublished - 2010 2月
外部発表はい

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング

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