Design of constant supersaturation cooling crystallization of a pharmaceutical: A simple approach

Keigo Hanaki*, Nobuaki Nonoyama, Yasuaki Yabuki, Yoshiaki Kato, Izumi Hirasawa

*この研究の対応する著者

研究成果査読

3 被引用数 (Scopus)

抄録

This paper describes a simple method for designing a batch cooling crystallization of a pharmaceutical under constant supersaturation. The simple model assumes that crystal growth is the predominant mechanism during the crystallization and requires only two parameters, crystal growth rate constant and solubility. Both parameters are functions of temperature and are obtained simultaneously by conducting a single experiment with multiple-step cooling. The model was validated through additional natural cooling and controlled cooling crystallization experiments. Finally, it was demonstrated experimentally that the supersaturation throughout the crystallization process was effectively kept constant by applying the cooling trajectory predicted by the model.

本文言語English
ページ(範囲)63-71
ページ数9
ジャーナルJOURNAL OF CHEMICAL ENGINEERING OF JAPAN
40
1
DOI
出版ステータスPublished - 2007 1月 19

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)

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