Detection of matrix metalloproteinase-2 by field effect transistor with a fibronectin-immobilized gate

Daisuke Yamamoto, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Tetsuya Osaka

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Matrix metalloproteinase (MMP) is known to be involved in chronic inflammation, tumor invasion, and carcinogenesis. To detect MMP-2, we examined the use of field effect transistors (FETs). After the addition of MMP-2 to a fibronectin (FN)- immobilized gate, negative value of FET response was observed, which indicates MMP-2 decreased the amount of negative charges arising from FN molecules. This FET device successfully detected MMP-2 by utilizing degradation of FN on the gate.

本文言語English
ページ(範囲)825-827
ページ数3
ジャーナルChemistry Letters
41
8
DOI
出版ステータスPublished - 2012

ASJC Scopus subject areas

  • Chemistry(all)

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