Determinants of Resting Oxidative Stress in Middle-Aged and Elderly Men and Women: WASEDA'S Health Study

Takuji Kawamura*, Kumpei Tanisawa, Ryoko Kawakami, Chiyoko Usui, Tomoko Ito, Hiroki Tabata, Nobuhiro Nakamura, Sayaka Kurosawa, Wonjun Choi, Sihui Ma, Zsolt Radak, Susumu S. Sawada, Katsuhiko Suzuki, Kaori Ishii, Shizuo Sakamoto, Koichiro Oka, Mitsuru Higuchi, Isao Muraoka

*この研究の対応する著者

研究成果: Article査読

抄録

Previous studies have not investigated the determinants of resting oxidative stress, including physical fitness, as it relates to redox regulation. The present study therefore was aimed at identifying lifestyle and biological factors that determine resting oxidative stress, including objectively measured physical fitness. In 873 middle-aged and elderly men and women, age and anthropometric parameters, lifestyle-related parameters, medication and supplementation status, physical fitness, biochemical parameters, and nutritional intake status, as well as three plasma oxidative stress markers: protein carbonyl (PC), F2-isoprostane (F2-IsoP), and thiobarbituric acid reactive substances (TBARS), were surveyed and measured. The determinants of PC, F2-IsoP, and TBARS in all participants were investigated using stepwise multiple regression analysis. In PC, age (β=-0.11, P=0.002), leg extension power (β=-0.12, P=0.008), BMI (β=0.12, P=0.004), and HDL-C (β=0.08, P=0.040) were included in the regression model (adjusted R2=0.018). In the F2-IsoP, smoking status (β=0.07, P=0.060), BMI (β=0.07, P=0.054), and HbA1c (β=-0.06, P=0.089) were included in the regression model (adjusted R2=0.006). In TBARS, glucose (β=0.18, P<0.001), CRF (β=0.16, P<0.001), age (β=0.15, P<0.001), TG (β=0.11, P=0.001), antioxidant supplementation (β=0.10, P=0.002), and HbA1c (β=-0.13, P=0.004) were included in the regression model (adjusted R2=0.071). In conclusion, the present study showed that age, anthropometric index, lifestyle-related parameters, medication and supplementation status, objectively measured physical fitness, biochemical parameters, and nutritional intake status explain less than 10% of oxidative stress at rest.

本文言語English
論文番号5566880
ジャーナルOxidative medicine and cellular longevity
2021
DOI
出版ステータスPublished - 2021

ASJC Scopus subject areas

  • 生化学
  • 加齢科学
  • 細胞生物学

フィンガープリント

「Determinants of Resting Oxidative Stress in Middle-Aged and Elderly Men and Women: WASEDA'S Health Study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル