Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells

Junichiro Yamaguchi, Hideaki Kakeya, Takao Uno, Mitsuru Shoji, Hiroyuki Osada, Yujiro Hayashi

研究成果: Article

24 被引用数 (Scopus)

抄録

(Chemical Equation Presented) A biomimetic pathway to lucilactaene (1) from NG-391 has been developed which involves stereoselective reactions under very mild conditions. It was demonstrated that 1 racemizes rapidly, and the conditions under which racemization occurs were elucidated. Lucilactaene (1) isolated under neutral conditions is racemic, which suggests that either the natural product is racemized rapidly in the mycelia, or racemic 1 is biosynthesized.

本文言語English
ページ(範囲)3110-3115
ページ数6
ジャーナルAngewandte Chemie - International Edition
44
20
DOI
出版ステータスPublished - 2005 5 13
外部発表はい

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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