Development of a stimuli-responsive polymer nanocomposite toward biologically optimized, MEMS-based neural probes

A. E. Hess, J. R. Capadona, K. Shanmuganathan, L. Hsu, S. J. Rowan, C. Weder, D. J. Tyler, C. A. Zorman

研究成果: Article査読

64 被引用数 (Scopus)

抄録

This paper reports the development of micromachining processes and mechanical evaluation of a stimuli-responsive, mechanically dynamic polymer nanocomposite for biomedical microsystems. This nanocomposite consists of a cellulose nanofiber network encased in a polyvinyl acetate matrix. Micromachined tensile testing structures fabricated from the nanocomposite displayed a reversible and switchable stiffness comparable to bulk samples, with a Young's modulus of 3420 MPa when dry, reducing to ∼20 MPa when wet, and a stiff-to-flexible transition time of ∼300 s. This mechanically dynamic behavior is particularly attractive for the development of adaptive intracortical probes that are sufficiently stiff to insert into the brain without buckling, but become highly compliant upon insertion. Along these lines, a micromachined neural probe incorporating parylene insulating/moisture barrier layers and Ti/Au electrodes was fabricated from the nanocomposite using a fabrication process designed specifically for this chemical- and temperature-sensitive material. It was found that the parylene layers only slightly increased the stiffness of the probe in the wet state in spite of its much higher Young's modulus. Furthermore, the Ti/Au electrodes exhibited impedance comparable to Au electrodes on conventional substrates. Swelling of the nanocomposite was highly anisotropic favoring the thickness dimension by a factor of 8 to 12, leading to excellent adhesion between the nanocomposite and parylene layers and no discernable deformation of the probes when deployed in deionized water.

本文言語English
論文番号054009
ジャーナルJournal of Micromechanics and Microengineering
21
5
DOI
出版ステータスPublished - 2011 5
外部発表はい

ASJC Scopus subject areas

  • 機械工学
  • 電子工学および電気工学
  • 材料力学
  • 電子材料、光学材料、および磁性材料

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