Development of catalytic asymmetric intramolecular cyclopropanation of α-diazo-β-keto sulfones and applications to natural product synthesis

Masahiro Honma, Hiroyuki Takeda, Masashi Takano, Masahisa Nakada*

*この研究の対応する著者

研究成果: Review article査読

48 被引用数 (Scopus)

抄録

The catalytic asymmetric intramolecular cyclopropanation (CAIMCP) of α-diazo-β-keto sulfones developed in our laboratory and applications to the total synthesis of natural products are described. CAIMCP features (a) a wide applicability, not only to the preparation of bicyclo[n.1.0]alkanes and tricyclo[4.n.0.0]alkenes, but also to the enantioselective total synthesis of natural products, (b) the formation of highly crystalline products, which facilitate the production of enantiomerically pure synthetic intermediates, and (c) the generation of products with a variety of functionalities, such as cyclopropane, ketone, and sulfone, beneficial to the total synthesis of natural products.

本文言語English
ページ(範囲)1695-1712
ページ数18
ジャーナルSynlett
11
DOI
出版ステータスPublished - 2009 7月 1

ASJC Scopus subject areas

  • 有機化学

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