Development of Chemical Substances Regulating Biofilm Formation

Akihiro Yamada, Hitomi Kitamura, Kaori Yamaguchi, Seketsu Fukuzawa, Chiyuki Kamijima, Kazunaga Yazawa, Makoto Kuramoto, Gui Yang Sheng Wang, Yasuyuki Fujitani, Daisuke Uemura*

*この研究の対応する著者

研究成果: Article査読

69 被引用数 (Scopus)

抄録

The chemical substances which regulate biofilm formation were examined, and a bioassay system which uses marine bacteria with adhering properties was developed. This bioassay system is suitable for screening crude extracts from marine organisms. Using this system, those substances which regulate biofilm formation were isolated from marine organisms. For example, bis(deacetyl)solenolide D was obtained from the marine sponge Psammaplysilla purpurea. Novel nitroalkanes were also isolated from the Okinawan sponge Callyspongia sp. Ethyl N-(2-phenylethyl)carbamate isolated from the marine bacteria SCRC3P79 (Cytophaga sp.) inhibited biofilm formation. Furthermore, the N,N-dichloro, isocyanide, isothiocyanate, and dithiocarbamate derivatives of 2-(4-nitrophenyl)ethylamine, significantly inhibited the growth of marine attaching bacteria. Interestingly, most of the marine sponges examined contained anti-biofilm compounds, such as benzoic acid, aeroplysinin-I, and bromoageliferin.

本文言語English
ページ(範囲)3061-3069
ページ数9
ジャーナルBulletin of the Chemical Society of Japan
70
12
出版ステータスPublished - 1997 12月
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)

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