抄録
Transition metal-catalyzed cross-coupling between aryl halides and nucleophiles is one of the most reliable C-C and C-heteroatom bond forming reactions. However, preparation of haloarenes usually requires multi-step operation, making the whole cross-coupling process inefficient. Nitroarenes, synthesized by a single-step nitration of arenes, can be attractive alternatives as electrophiles in cross-coupling methodology, but inherent inertness of C(sp 2)-NO 2 bonds toward metal catalysts has been a bottleneck of general denitrative transformations. Recently, we have overcome this obstacle and achieved direct activation of Ar-NO 2 bonds by using Pd/BrettPhos catalysis. Herein, we describe the development of denitrative couplings by Pd/BrettPhos catalyst and its unique suitability from a mechanistic point of view. Deep understanding of reaction mechanism also enabled us to design more active Pd/NHC system.
本文言語 | English |
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ページ(範囲) | 11-21 |
ページ数 | 11 |
ジャーナル | Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry |
巻 | 79 |
号 | 1 |
DOI | |
出版ステータス | Published - 2021 1月 1 |
ASJC Scopus subject areas
- 有機化学