Development of silicon-tethered anionic reaction and its application to the synthesis of chiral A-ring moieties of Taxol™

Mitsuhiro Iwamoto, Masayuki Miyano, Masayuki Utsugi, Hatsuo Kawada, Masahisa Nakada

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Silicon-tethered intramolecular nucleophilic additions of a hydroxymethyl unit to ketones in β-hydroxyketones have been developed. The product obtained by this protocol was successfully converted to chiral A-ring moieties of Taxol™. Also developed was a promising silicon-tethered intramolecular α-alkylation reaction of the cyclic hydroxyketone.

本文言語English
ページ(範囲)8647-8651
ページ数5
ジャーナルTetrahedron Letters
45
47
DOI
出版ステータスPublished - 2004 11月 15

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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