Developmental neurotoxicity of dioxin and its related compounds

Masaki Kakeyama*, Chiharu Tohyama

*この研究の対応する著者

研究成果: Review article査読

59 被引用数 (Scopus)

抄録

This manuscript reviewed the neurotoxicity of dioxins and related compounds with an emphasis on maternal exposure. The brain during developmental period is thought to be highly sensitive to dioxin and its related compounds that affect a broad range of brain functions from the advanced brain function to the reproduction-controlling function, even at low doses. It is suggested that dioxins exhibit endocrine-disrupting action on the gonadal and thyroid hormone axes, as well as the 'neural-disrupting action' on neural transmission and neural network formation. From behavioral toxicological studies as well as studies on the underlying mechanisms of dioxins' toxicity, dioxins affect some specific functions in particular regions or cells of the brain at critical windows during the developmental period.

本文言語English
ページ(範囲)215-230
ページ数16
ジャーナルIndustrial Health
41
3
DOI
出版ステータスPublished - 2003 7
外部発表はい

ASJC Scopus subject areas

  • 公衆衛生学、環境および労働衛生
  • 健康、毒物学および変異誘発

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