Diacylglycerol kinase defect in a Drosophila retinal degeneration mutant rdgA

H. Inoue, T. Yoshioka, Y. Hotta

    研究成果: Article

    58 引用 (Scopus)

    抜粋

    The Drosophila visual mutant rdgA is known to show age-dependent retinal degeneration with defective diacylglycerol (DG) kinase activity. In this study we examined DG kinase activity of several visual mutants and found that only rdgA mutant eyes showed the lack of DG kinase activity in a gene dosage-dependent manner. The enzyme activity is already absent at the time of eclosion from pupal case when the degeneration is not yet apparent. To examine whether rdgA gene dosage effect holds for other enzymes related to the phosphatidylinositol turnover, phospholipase C was analyzed which did not show any gene dosage effect. Therefore, it is strongly suggested that rdgA gene correlates closely with DG kinase activity, and the defect of DG kinase activity is a primary cause of retinal degeneration in rdgA mutant.

    元の言語English
    ページ(範囲)5996-6000
    ページ数5
    ジャーナルJournal of Biological Chemistry
    264
    発行部数10
    出版物ステータスPublished - 1989

      フィンガープリント

    ASJC Scopus subject areas

    • Biochemistry

    これを引用