Diagnostic accuracy of serological kits for Helicobacter pylori infection with the same assay system but different antigens in a Japanese patient population

Yuki Obata, Shogo Kikuchi*, Hiroto Miwa, Kiyoko Yagyu, Yingsong Lin, Atsushi Ogihara

*この研究の対応する著者

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Helicobacter pylori infection is thought to be a causal risk factor for gastric carcinoma. Recently, diagnostic accuracy of serological kits for H. pylori infection that were made in Western countries has been reported to be lower when used among Oriental populations. Diagnostic accuracy of two serological kits [HM-CAP and HM-CAP with antigens extracted from clinically isolated Japanese H. pylori strains (J-HM-CAP)] was investigated in 440 samples from a Japanese patient population by using the 13C-urea breath test as gold standard. According to the original optimal cut-off value, HM-CAP provided 87.5% sensitivity and 84.8% specificity with 86.8% accuracy and J-HM-CAP provided 95.5% sensitivity and 81.9% specificity with 92.3% accuracy. This study suggests that antigens from HM-CAP are satisfactory for examining a Japanese patient population, but that using local antigens improves accuracy.

本文言語English
ページ(範囲)889-892
ページ数4
ジャーナルJournal of Medical Microbiology
52
10
DOI
出版ステータスPublished - 2003 10
外部発表はい

ASJC Scopus subject areas

  • 微生物学
  • 微生物学(医療)

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