Diamond electrolyte solution gate FETs for DNA and protein sensors using DNA/RNA aptamers

H. Kawarada, A. R. Ruslinda

研究成果: Article査読

46 被引用数 (Scopus)

抄録

For DNA and protein detection, we have analyzed DNA/RNA immobilized biosensors based on diamond field effect transistors (FETs), where several types of atomic or molecule termination have been realized on their surfaces. Amine termination and carboxyl termination necessary for biomolecule immobilization can be formed directly on the diamond surfaces resulting in the immobilization of short DNA/RNA within 5nm from the surface. Owing to the high areal capacitance of a liquid electric double layer capacitor and a solid channel capacitor, the change in the surface charge caused by the hybridization of DNA/RNA and the protein binding to DNA/RNA aptamers can be efficiently detected. The charge of surface termination groups such as NH 3 +, O -, COO - affects the suppression of nonspecific binding. The detection of biomolecules such as one-base mismatch of DNA and proteins that is unaffected by nonspecific binding can be realized as a result.

本文言語English
ページ(範囲)2005-2016
ページ数12
ジャーナルPhysica Status Solidi (A) Applications and Materials Science
208
9
DOI
出版ステータスPublished - 2011 9

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学
  • 表面および界面
  • 表面、皮膜および薄膜
  • 電子工学および電気工学
  • 材料化学

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