Dietary Effects of Eicosapentaenoic and Docosahexaenoic Acid Esters on Lipid Metabolism and Immune Parameters in Sprague-Dawley Rats

Pham Hung, Jiong Yan Gu, Shihoko Kaku, Shin Ichi Yunoki, Ken Ichi Ohkura, Ikuo Ikeda, Hirofumi Tachibana, Michihiro Sugano, Kazunaga Yazawa, Koji Yamada

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Sprague-Dawley rats were fed eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) ethyl esters at the 2% level for 3 weeks to clarify their effects on immune functions. In the rats fed EPA or DHA, serum cholesterol, triglyceride, and phospholipid (PL) levels were significantly lower than those in the rats fed safflower oil. In PL fractions of serum, liver, lung, splenocytes, and peritoneal exudate cells (PEC), increases in linoleic and dihomo-γ-linolenic acid contents and a decrease in arachidonic acid (AA) content were observed in the rats fed EPA or DHA. In addition, the EPA content increased in the rats fed EPA and DHA. In the rats fed EPA or DHA, a decrease of LTB4 productivity and an increase of LTB5 productivity were observed in the PEC, in response to the treatment with 5 μM calcium ionophore A23187 for 20 min. The changes in leukotriene production were more marked in EPA-fed rats than in DHA-fed rats. These results suggest that dietary EPA affects lipid metabolism and leukotriene synthesis more strongly than DHA.

本文言語English
ページ(範囲)2588-2593
ページ数6
ジャーナルBioscience, Biotechnology and Biochemistry
64
12
出版ステータスPublished - 2000 12
外部発表はい

ASJC Scopus subject areas

  • 食品科学
  • 生化学、遺伝学、分子生物学(全般)
  • 生化学
  • バイオテクノロジー
  • 化学(その他)
  • 応用微生物学とバイオテクノロジー
  • バイオエンジニアリング

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