Dietary glycemic index and glycemic load in relation to HbA1c in Japanese obese adults: A cross-sectional analysis of the Saku Control Obesity Program

Maki Goto, Akemi Morita, Atsushi Goto, Satoshi Sasaki, Naomi Aiba, Takuro Shimbo, Yasuo Terauchi, Motohiko Miyachi, Mitsuhiko Noda*, Shaw Watanabe

*この研究の対応する著者

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Background: Dietary glycemic index or load is thought to play an important role in glucose metabolism. However, few studies have investigated the relation between glycemic index (GI) or load (GL) and glycemia in Asian populations. In this cross-sectional analysis of a randomized controlled trial, the Saku Control Obesity Program, we examined the relation between the baseline GI or GL and glycemia (HbA1c and fasting plasma glucose [FPG] levels), insulin resistance (HOMA-IR), β-cell function (HOMA-β), and other metabolic risk factors (lipid levels, diastolic and systolic blood pressure, and adiposity measures). Methods. The participants were 227 obese Japanese women and men. We used multiple linear regression models and logistic regression models to adjust for potential confounding factors such as age, sex, visceral fat area, total energy intake, and physical activity levels. Results: After adjustments for potential confounding factors, GI was not associated with HbA1c, but GL was positively associated with HbA1c. For increasing quartiles of GI, the adjusted mean HbA1c were 6.3%, 6.7%, 6.4%, and 6.4% (P for trend=0.991). For increasing quartiles of GL, the adjusted mean HbA1c were 6.2%, 6.2%, 6.6%, and 6.5% (P for trend=0.044). In addition, among participants with HbA1c≥7.0%, 20 out of 28 (71%) had a high GL (≥ median); the adjusted odds ratio for HbA1c≥7.0% among participants with higher GL was 3.1 (95% confidence interval [CI]=1.2 to 8.1) compared to the participants with a lower GL (<median). Further, among 16 participants with FPG≥150 mg/dL, 13 participants (81.3%) had a higher GL; the adjusted odds ratio for FPG≥150 mg/dL among participants with a higher GL was 8.5 (95% confidence interval=1.7 to 43.4) compared to those with a lower GL. In contrast, GI and GL were not associated with metabolic risk factors other than glycemia. Conclusions: Our findings suggest that participants with poor glycemic control tend to have a higher GL in an obese Japanese population.

本文言語English
論文番号79
ジャーナルNutrition and Metabolism
9
DOI
出版ステータスPublished - 2012
外部発表はい

ASJC Scopus subject areas

  • 医学(その他)
  • 内分泌学、糖尿病および代謝内科学
  • 栄養および糖尿病

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