Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g

Chie Matsuda, Tamotsu Kato, Sayo Inoue-Suzuki, Jun Kikuchi, Toshiko Ohta, Masaharu Kagawa, Masahira Hattori, Hiroe Kobayashi, Dai Shiba, Masaki Shirakawa, Hiroyasu Mizuno, Satoshi Furukawa, Chiaki Mukai, Hiroshi Ohno

研究成果: Article

2 引用 (Scopus)

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Japan Aerospace Exploration Agency (JAXA) has developed mouse habitat cage units equipped with an artificial gravity-producing centrifuge, called the Multiple Artificial-gravity Research System (MARS), that enables single housing of a mouse under artificial gravity (AG) in orbit. This is a report on a hardware evaluation. The MARS underwent improvement in water leakage under microgravity (MG), and was used in the second JAXA mouse mission to evaluate the effect of AG and diet on mouse biological system simultaneously. Twelve mice were divided into four groups of three, with each group fed a diet either with or without fructo-oligosaccharide and housed singly either at 1 g AG or MG for 30 days on the International Space Station, then safely returned to the Earth. Body weight tended to increase in AG mice and decrease in MG mice after spaceflight, but these differences were not significant. This indicates that the improved MARS may be useful in evaluating AG and dietary intervention for space flown mice.

元の言語English
記事番号16
ジャーナルnpj Microgravity
5
発行部数1
DOI
出版物ステータスPublished - 2019 12 1

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ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Materials Science (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Agricultural and Biological Sciences (miscellaneous)
  • Physics and Astronomy (miscellaneous)
  • Space and Planetary Science

これを引用

Matsuda, C., Kato, T., Inoue-Suzuki, S., Kikuchi, J., Ohta, T., Kagawa, M., Hattori, M., Kobayashi, H., Shiba, D., Shirakawa, M., Mizuno, H., Furukawa, S., Mukai, C., & Ohno, H. (2019). Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1 g. npj Microgravity, 5(1), [16]. https://doi.org/10.1038/s41526-019-0077-0