Difference in self-assembling morphology of peptide nanorings

Hajime Okamoto, Tetsuo Yamada, Hiroshi Miyazaki, Tsutomu Nakanishi, Kyozaburo Takeda, Kenji Usui, Ikuo Obataya, Hisakazu Mhara, Hiroaki Azehara, Wataru Mizutani, Katsushi Hashimoto, Hiroshi Yamaguchi, Yoshiro Hirayama

    研究成果: Article

    4 引用 (Scopus)

    抄録

    We synthesized the peptide nanorings of cyclo[-(D-Ala-L-Gln)3], cyclo[-(D-Cys-L-Gln)3], cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] and cyclo[-(L-Gln)3], and studied the way in which the difference in the type and/or number of component amino acid residues changes the self-assembling morphology of the nanorings on gold substrates by atomic force microscopy. The study revealed that cyclo[-(D-Ala-L-Gln)3] formed nanotube bundles through inter-ring hydrogen bonds, while the nanorings of cyclo[-(D-Cys-L-Gln)3] adhered to the gold surface directly due to the high affinity of thiol to gold. In contrast, a random amino acid sequence of cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] resulted in many isolated nanotubes, which were first observed in the present study. While the D,L-peptide nanotubes have very straight forms, the homo-L-peptide of cyclo[-(L-Gln)5] formed interesting randomly branching nanotubes that were entwined and grew on the substrate. Scanning tunneling microscopy was also performed and high-resolution images of both the peptide nanotubes and the nanotube bundles were obtained.

    元の言語English
    ページ(範囲)8240-8248
    ページ数9
    ジャーナルJapanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
    44
    発行部数11
    DOI
    出版物ステータスPublished - 2005 11 9

    Fingerprint

    Nanorings
    assembling
    Nanotubes
    Peptides
    peptides
    nanotubes
    Gold
    gold
    bundles
    amino acids
    Amino acids
    Scanning tunneling microscopy
    Substrates
    Image resolution
    thiols
    affinity
    scanning tunneling microscopy
    Atomic force microscopy
    Hydrogen bonds
    atomic force microscopy

    ASJC Scopus subject areas

    • Physics and Astronomy (miscellaneous)

    これを引用

    Difference in self-assembling morphology of peptide nanorings. / Okamoto, Hajime; Yamada, Tetsuo; Miyazaki, Hiroshi; Nakanishi, Tsutomu; Takeda, Kyozaburo; Usui, Kenji; Obataya, Ikuo; Mhara, Hisakazu; Azehara, Hiroaki; Mizutani, Wataru; Hashimoto, Katsushi; Yamaguchi, Hiroshi; Hirayama, Yoshiro.

    :: Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers, 巻 44, 番号 11, 09.11.2005, p. 8240-8248.

    研究成果: Article

    Okamoto, H, Yamada, T, Miyazaki, H, Nakanishi, T, Takeda, K, Usui, K, Obataya, I, Mhara, H, Azehara, H, Mizutani, W, Hashimoto, K, Yamaguchi, H & Hirayama, Y 2005, 'Difference in self-assembling morphology of peptide nanorings', Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers, 巻. 44, 番号 11, pp. 8240-8248. https://doi.org/10.1143/JJAP.44.8240
    Okamoto, Hajime ; Yamada, Tetsuo ; Miyazaki, Hiroshi ; Nakanishi, Tsutomu ; Takeda, Kyozaburo ; Usui, Kenji ; Obataya, Ikuo ; Mhara, Hisakazu ; Azehara, Hiroaki ; Mizutani, Wataru ; Hashimoto, Katsushi ; Yamaguchi, Hiroshi ; Hirayama, Yoshiro. / Difference in self-assembling morphology of peptide nanorings. :: Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers. 2005 ; 巻 44, 番号 11. pp. 8240-8248.
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    abstract = "We synthesized the peptide nanorings of cyclo[-(D-Ala-L-Gln)3], cyclo[-(D-Cys-L-Gln)3], cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] and cyclo[-(L-Gln)3], and studied the way in which the difference in the type and/or number of component amino acid residues changes the self-assembling morphology of the nanorings on gold substrates by atomic force microscopy. The study revealed that cyclo[-(D-Ala-L-Gln)3] formed nanotube bundles through inter-ring hydrogen bonds, while the nanorings of cyclo[-(D-Cys-L-Gln)3] adhered to the gold surface directly due to the high affinity of thiol to gold. In contrast, a random amino acid sequence of cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] resulted in many isolated nanotubes, which were first observed in the present study. While the D,L-peptide nanotubes have very straight forms, the homo-L-peptide of cyclo[-(L-Gln)5] formed interesting randomly branching nanotubes that were entwined and grew on the substrate. Scanning tunneling microscopy was also performed and high-resolution images of both the peptide nanotubes and the nanotube bundles were obtained.",
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    T1 - Difference in self-assembling morphology of peptide nanorings

    AU - Okamoto, Hajime

    AU - Yamada, Tetsuo

    AU - Miyazaki, Hiroshi

    AU - Nakanishi, Tsutomu

    AU - Takeda, Kyozaburo

    AU - Usui, Kenji

    AU - Obataya, Ikuo

    AU - Mhara, Hisakazu

    AU - Azehara, Hiroaki

    AU - Mizutani, Wataru

    AU - Hashimoto, Katsushi

    AU - Yamaguchi, Hiroshi

    AU - Hirayama, Yoshiro

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    N2 - We synthesized the peptide nanorings of cyclo[-(D-Ala-L-Gln)3], cyclo[-(D-Cys-L-Gln)3], cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] and cyclo[-(L-Gln)3], and studied the way in which the difference in the type and/or number of component amino acid residues changes the self-assembling morphology of the nanorings on gold substrates by atomic force microscopy. The study revealed that cyclo[-(D-Ala-L-Gln)3] formed nanotube bundles through inter-ring hydrogen bonds, while the nanorings of cyclo[-(D-Cys-L-Gln)3] adhered to the gold surface directly due to the high affinity of thiol to gold. In contrast, a random amino acid sequence of cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] resulted in many isolated nanotubes, which were first observed in the present study. While the D,L-peptide nanotubes have very straight forms, the homo-L-peptide of cyclo[-(L-Gln)5] formed interesting randomly branching nanotubes that were entwined and grew on the substrate. Scanning tunneling microscopy was also performed and high-resolution images of both the peptide nanotubes and the nanotube bundles were obtained.

    AB - We synthesized the peptide nanorings of cyclo[-(D-Ala-L-Gln)3], cyclo[-(D-Cys-L-Gln)3], cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] and cyclo[-(L-Gln)3], and studied the way in which the difference in the type and/or number of component amino acid residues changes the self-assembling morphology of the nanorings on gold substrates by atomic force microscopy. The study revealed that cyclo[-(D-Ala-L-Gln)3] formed nanotube bundles through inter-ring hydrogen bonds, while the nanorings of cyclo[-(D-Cys-L-Gln)3] adhered to the gold surface directly due to the high affinity of thiol to gold. In contrast, a random amino acid sequence of cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] resulted in many isolated nanotubes, which were first observed in the present study. While the D,L-peptide nanotubes have very straight forms, the homo-L-peptide of cyclo[-(L-Gln)5] formed interesting randomly branching nanotubes that were entwined and grew on the substrate. Scanning tunneling microscopy was also performed and high-resolution images of both the peptide nanotubes and the nanotube bundles were obtained.

    KW - Atomic force microscopy

    KW - Cyclic peptide

    KW - Nanotube

    KW - Scanning tunneling microscopy

    KW - Self-assembly, synthesis

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