Differential acylated ghrelin, peptide YY3-36, appetite, and food intake responses to equivalent energy deficits created by exercise and food restriction

James A. King, Lucy K. Wasse, Joshua Ewens, Kathrina Crystallis, Julian Emmanuel, Rachel L. Batterham, David J. Stensel

研究成果: Article査読

104 被引用数 (Scopus)

抄録

Context: Acute energy deficits imposed by food restriction increase appetite and energy intake; however, these outcomes remain unchanged when energy deficits are imposed by exercise. Objective:Ourobjectivewasto determine the potential role of acylated ghrelinandpeptideYY3-36 (PYY 3-36) in mediating appetite and energy intake responses to identical energy deficits imposed by food restriction and exercise. Design: Twelve healthy males completed three 9-h trials (exercise deficit, food deficit, and control) in a randomized counterbalanced design. Participants ran for 90 min (70% of VO2 max) at the beginning of the exercise deficit trial and then rested for 7.5 h. Participants remained sedentary throughout the food deficit and control trials. Test meals were consumed by participants at 2 and 4.75 h in all trials. The amount provided in the food deficit trial was restricted so that an energy deficit (equivalent to that imposed by exercise) was induced relative to control. Participants were permitted access to a buffet meal at 8 h. Results: The energy deficits imposed by food restriction (4820 ± 151 kJ) and exercise (4715 ± 113 kJ) were similar. Appetite and ad libitum energy intake responded in a compensatory fashion to food restriction yet were not influenced by exercise. Plasma acylated ghrelin concentrations increased, whereas PYY3-36 decreased, in response to food restriction (two-way ANOVA, trial×time interaction, P < 0.001 for each). Exercise did not induce such compensatory responses. Conclusions: These findings suggest a mediating role of acylated ghrelin and PYY3-36 in determining divergent feeding responses to energy deficits imposed by food restriction and exercise.

本文言語English
ページ(範囲)1114-1121
ページ数8
ジャーナルJournal of Clinical Endocrinology and Metabolism
96
4
DOI
出版ステータスPublished - 2011 4月
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 内分泌学
  • 臨床生化学
  • 生化学、医学

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