Differential sympathetic outflow and vasoconstriction responses at kidney and skeletal muscles during fictive locomotion

Satoshi Koba, Takayoshi Yoshida, Naoyuki Hayashi*

*この研究の対応する著者

研究成果: Article査読

22 被引用数 (Scopus)

抄録

We compared sympathetic and circulatory responses between kidney and skeletal muscles during fictive locomotion evoked by electrical stimulation of the mesencephalic locomotor region (MLR) in decerebrate and paralyzed rats (n = 8). Stimulation of the MLR for 30 s at 40-μA current intensity significantly increased arterial pressure (+38 ± 6 mmHg), triceps surae muscle blood flow (+17 ± 3%), and both renal and lumbar sympathetic nerve activities (RSNA +113 ± 16%, LSNA +31 ± 7%). The stimulation also significantly decreased renal cortical blood flow (-18 ± 6%) and both renal cortical and triceps surae muscle vascular conductances (RCVC -38 ± 5%, TSMVC -17 ± 3%). The sympathetic and vascular conductance changes were significantly dependent on current intensity for stimulation at 20, 30, and 40 μA. The changes in LSNA and TSMVC were significantly less than those in RSNA and RCVC, respectively, at all current intensities. At the early stage of stimulation (0-10 s), decreases in RCVC and TSMVC were significantly correlated with increases in RSNA and LSNA, respectively. These data demonstrate that fictive locomotion induces less vasoconstriction in skeletal muscles than in kidney because of less sympathetic activation. This suggests that a neural mechanism mediated by central command contributes to blood flow distribution by evoking differential sympathetic outflow during exercise.

本文言語English
ページ(範囲)H861-H868
ジャーナルAmerican Journal of Physiology - Heart and Circulatory Physiology
290
2
DOI
出版ステータスPublished - 2006 2
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 循環器および心血管医学
  • 生理学(医学)

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