Differentiating the roles of microtubule-associated proteins at meiotic kinetochores during chromosome segregation

Yasutaka Kakui*, Masamitsu Sato

*この研究の対応する著者

研究成果: Review article査読

3 被引用数 (Scopus)

抄録

Meiosis is a specialised cell division process for generating gametes. In contrast to mitosis, meiosis involves recombination followed by two consecutive rounds of cell division, meiosis I and II. A vast field of research has been devoted to understanding the differences between mitotic and meiotic cell divisions from the viewpoint of chromosome behaviour. For faithful inheritance of paternal and maternal genetic information to offspring, two events are indispensable: meiotic recombination, which generates a physical link between homologous chromosomes, and reductional segregation, in which homologous chromosomes move towards opposite poles, thereby halving the ploidy. The cytoskeleton and its regulators play specialised roles in meiosis to accomplish these divisions. Recent studies have shown that microtubule-associated proteins (MAPs), including tumour overexpressed gene (TOG), play unique roles during meiosis. Furthermore, the conserved mitotic protein kinase Polo modulates MAP localisation in meiosis I. As Polo is a well-known regulator of reductional segregation in meiosis, the evidence suggests that Polo constitutes a plausible link between meiosis-specific MAP functions and reductional segregation. Here, we review the latest findings on how the localisation and regulation of MAPs in meiosis differ from those in mitosis, and we discuss conservation of the system between yeast and higher eukaryotes.

本文言語English
ページ(範囲)309-320
ページ数12
ジャーナルChromosoma
125
2
DOI
出版ステータスPublished - 2016 6 1

ASJC Scopus subject areas

  • 遺伝学
  • 遺伝学(臨床)

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