Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-94

Islam A. Abdelhakim, Fauze Bin Mahmud, Takayuki Motoyama, Yushi Futamura, Shunji Takahashi, Hiroyuki Osada*

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A recently discovered secondary metabolism regulator, NPD938, was used to alter the secondary metabolite profile in Fusarium sp. RK97-94. Three lucilactaene analogues were detected via UPLC-ESI-MS analysis in NPD938-treated culture. The three metabolites were successfully purified and identified as dihydroNG391 (1), dihydrolucilactaene (2), and 13α-hydroxylucilactaene (3) via extensive spectroscopic analyses. DihydroNG391 (1) exhibited weak in vitro antimalarial activity (IC50 = 62 μM). In contrast, dihydrolucilactaene (2) and 13α-hydroxylucilactaene (3) showed very potent antimalarial activity (IC50 = 0.0015 and 0.68 μM, respectively). These findings provide insight into the structure–activity relationship of lucilactaene and its analogues as antimalarial lead compounds.

本文言語English
ページ(範囲)63-69
ページ数7
ジャーナルJournal of Natural Products
85
1
DOI
出版ステータスPublished - 2022 1月 28
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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