Dipyrimicin A and B, microbial compounds isolated from Amycolatopsis sp. K16-0194

Shoko Izuta, Shohei Kosaka, Makoto Kawai, Rei Miyano, Hirotaka Matsuo, Atsuko Matsumoto, Kenichi Nonaka, Yoko Takahashi, Satoshi Omura, Takuji Nakashima*

*この研究の対応する著者

研究成果: Article査読

16 被引用数 (Scopus)

抄録

In a search for compounds interacting with ergosterol resin, a new compound named dipyrimicin B was isolated from a rare actinomycete strain, Amycolatopsis sp. K16-0194. In addition, another analog, dipyrimicin A, which does not interact with the resin, was also discovered. The structures of the two dipyrimicins were established by comprehensive 1D and 2D NMR and MS analyses and found to contain a unique core structure, a 2,2′-bipyridine skeleton. Dipyrimicin A showed strong antimicrobial and cytotoxic activity, whereas dipyrimicin B displayed distinctly poor antimicrobial and cytotoxic activities.

本文言語English
ページ(範囲)535-537
ページ数3
ジャーナルJournal of Antibiotics
71
5
DOI
出版ステータスPublished - 2018 5月 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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