抄録
trans-tert-Butyldimethylsiloxy-l-proline displays greater catalytic activity and affords higher enantioselectivity than the parent proline in the a-amination reaction of carbonyl compounds with azodicarboxylate. A quantum mechanical calculation reveals the structure of the transition state. In the presence of a catalytic amount of siloxyproline and water (3-9 equiv), α-amino carbonyl derivatives, which are important synthetic intermediates, are obtained in good yield and with excellent enantioselectivity.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 225-232 |
| ページ数 | 8 |
| ジャーナル | Chemistry - An Asian Journal |
| 巻 | 3 |
| 号 | 2 |
| DOI | |
| 出版ステータス | Published - 2008 2月 1 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 有機化学