Direct reductive amination using triethylsilane and catalytic bismuth(III) chloride

Takehiko Matsumura, Masahisa Nakada*

*この研究の対応する著者

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Direct reductive amination (DRA) using triethylsilane (TESH) and catalytic bismuth(III) chloride (BiCl3) is described for the first time. The use of TESH and BiCl3 provides easy handling, low cost, non-toxicity, and a mild Lewis acid activity, thereby meeting the demand for green and sustainable chemistry. The developed DRA is highly chemoselective and applicable to less-basic amines. The experimental results of this study revealed that the developed DRA could be catalyzed by BiCl3, which was gradually reduced to Bi(0) or bismuth with a low valency by TESH, but TESCl, Bi(0), and Bi(0) with TESCl catalyzed the DRA to some extent.

本文言語English
ページ(範囲)1829-1834
ページ数6
ジャーナルTetrahedron Letters
55
10
DOI
出版ステータスPublished - 2014 3月 5

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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