Disposition control of metalloporphyrins as SOD mimics

Miho Tamai; Shoichiro Asayama; Shoji Nagaoka; Kenichi Oyaizu; Makoto Yuasa; Hiroyoshi Kawakami

Disposition control of metalloporphyrins as SOD mimics

Miho Tamai, Shoichiro Asayama, Shoji Nagaoka, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami

研究成果: Paper › 査読

抄録

We have reported the effects of metalloporphyrins as SOD mimics on the anticancer and antioxidation. Fe-porphyrins as SOD mimics convert intracellular O₂^- · to H₂O₂ and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally, H ₂O₂ and OH · generated by the Fe-porphyrin are expected to cause cell death. In this study, we have synthesized liposomes with water-soluble cationic metalloporphyrins as SOD mimic and have investigated the effect of the liposomes on cancer cell death. Liposomes were prepared using a sonication method. Cell viabilities of cell lines treated with Fe-porphyrins, liposomes containing Fe-porphyrins, and cisplatin were estimated by a Alamar Blue Assay. Liposomes containing Fe-porphyrins showed a significant cytotoxicity for cancer cell as compared with cisplatin.

本文言語	English
ページ	5195-5196
ページ数	2
出版ステータス	Published - 2005 12 1
外部発表	はい
イベント	54th SPSJ Symposium on Macromolecules - Yamagata, Japan 継続期間: 2005 9 20 → 2005 9 22

Other

Other	54th SPSJ Symposium on Macromolecules
Country	Japan
City	Yamagata
Period	05/9/20 → 05/9/22

ASJC Scopus subject areas

Engineering(all)

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引用スタイル

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title = "Disposition control of metalloporphyrins as SOD mimics",

abstract = "We have reported the effects of metalloporphyrins as SOD mimics on the anticancer and antioxidation. Fe-porphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally, H 2O2 and OH · generated by the Fe-porphyrin are expected to cause cell death. In this study, we have synthesized liposomes with water-soluble cationic metalloporphyrins as SOD mimic and have investigated the effect of the liposomes on cancer cell death. Liposomes were prepared using a sonication method. Cell viabilities of cell lines treated with Fe-porphyrins, liposomes containing Fe-porphyrins, and cisplatin were estimated by a Alamar Blue Assay. Liposomes containing Fe-porphyrins showed a significant cytotoxicity for cancer cell as compared with cisplatin.",

keywords = "Drug delivery system, Liposome, Metalloporphyrin, Signal Peptide",

author = "Miho Tamai and Shoichiro Asayama and Shoji Nagaoka and Kenichi Oyaizu and Makoto Yuasa and Hiroyoshi Kawakami",

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T1 - Disposition control of metalloporphyrins as SOD mimics

AU - Tamai, Miho

AU - Asayama, Shoichiro

AU - Nagaoka, Shoji

AU - Oyaizu, Kenichi

AU - Yuasa, Makoto

AU - Kawakami, Hiroyoshi

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We have reported the effects of metalloporphyrins as SOD mimics on the anticancer and antioxidation. Fe-porphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally, H 2O2 and OH · generated by the Fe-porphyrin are expected to cause cell death. In this study, we have synthesized liposomes with water-soluble cationic metalloporphyrins as SOD mimic and have investigated the effect of the liposomes on cancer cell death. Liposomes were prepared using a sonication method. Cell viabilities of cell lines treated with Fe-porphyrins, liposomes containing Fe-porphyrins, and cisplatin were estimated by a Alamar Blue Assay. Liposomes containing Fe-porphyrins showed a significant cytotoxicity for cancer cell as compared with cisplatin.

AB - We have reported the effects of metalloporphyrins as SOD mimics on the anticancer and antioxidation. Fe-porphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally, H 2O2 and OH · generated by the Fe-porphyrin are expected to cause cell death. In this study, we have synthesized liposomes with water-soluble cationic metalloporphyrins as SOD mimic and have investigated the effect of the liposomes on cancer cell death. Liposomes were prepared using a sonication method. Cell viabilities of cell lines treated with Fe-porphyrins, liposomes containing Fe-porphyrins, and cisplatin were estimated by a Alamar Blue Assay. Liposomes containing Fe-porphyrins showed a significant cytotoxicity for cancer cell as compared with cisplatin.

KW - Drug delivery system

KW - Liposome

KW - Metalloporphyrin

KW - Signal Peptide

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