Disposition control of metalloporphyrins as SOD mimics

Miho Tamai, Shoichiro Asayama, Shoji Nagaoka, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami

研究成果: Paper査読

抄録

We have reported the effects of metalloporphyrins as SOD mimics on the anticancer and antioxidation. Fe-porphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally, H 2O2 and OH · generated by the Fe-porphyrin are expected to cause cell death. In this study, we have synthesized liposomes with water-soluble cationic metalloporphyrins as SOD mimic and have investigated the effect of the liposomes on cancer cell death. Liposomes were prepared using a sonication method. Cell viabilities of cell lines treated with Fe-porphyrins, liposomes containing Fe-porphyrins, and cisplatin were estimated by a Alamar Blue Assay. Liposomes containing Fe-porphyrins showed a significant cytotoxicity for cancer cell as compared with cisplatin.

本文言語English
ページ5195-5196
ページ数2
出版ステータスPublished - 2005 12 1
外部発表はい
イベント54th SPSJ Symposium on Macromolecules - Yamagata, Japan
継続期間: 2005 9 202005 9 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

ASJC Scopus subject areas

  • Engineering(all)

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