Disrupted brain connectivity in children treated with therapeutic hypothermia for neonatal encephalopathy

Arthur P.C. Spencer, Jonathan C.W. Brooks, Naoki Masuda, Hollie Byrne, Richard Lee-Kelland, Sally Jary, Marianne Thoresen, James Tonks, Marc Goodfellow, Frances M. Cowan, Ela Chakkarapani*

*この研究の対応する著者

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Therapeutic hypothermia following neonatal encephalopathy due to birth asphyxia reduces death and cerebral palsy. However, school-age children without cerebral palsy treated with therapeutic hypothermia for neonatal encephalopathy still have reduced performance on cognitive and motor tests, attention difficulties, slower reaction times and reduced visuo-spatial processing abilities compared to typically developing controls. We acquired diffusion-weighted imaging data from school-age children without cerebral palsy treated with therapeutic hypothermia for neonatal encephalopathy at birth, and a matched control group. Voxelwise analysis (33 cases, 36 controls) confirmed reduced fractional anisotropy in widespread areas of white matter in cases, particularly in the fornix, corpus callosum, anterior and posterior limbs of the internal capsule bilaterally and cingulum bilaterally. In structural brain networks constructed using probabilistic tractography (22 cases, 32 controls), graph-theoretic measures of strength, local and global efficiency, clustering coefficient and characteristic path length were found to correlate with IQ in cases but not controls. Network-based statistic analysis implicated brain regions involved in visuo-spatial processing and attention, aligning with previous behavioural findings. These included the precuneus, thalamus, left superior parietal gyrus and left inferior temporal gyrus. Our findings demonstrate that, despite the manifest successes of therapeutic hypothermia, brain development is impaired in these children.

本文言語English
論文番号102582
ジャーナルNeuroImage: Clinical
30
DOI
出版ステータスPublished - 2021 1
外部発表はい

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング
  • 神経学
  • 臨床神経学
  • 認知神経科学

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