Distribution of novel RFamide-related peptide-like immunoreactivity in the mouse central nervous system

Kazuyoshi Ukena*, Kazuyoshi Tsutsui

*この研究の対応する著者

研究成果: Article査読

93 被引用数 (Scopus)

抄録

Recently, novel mammalian RFamide-related peptides (RFRPs) have been identified and suggested to increase prolactin release in the rodent. To assess possible functions of RFRPs, we investigated the distribution of RFRPs in the mouse central nervous system by immunochemical analyses. The quantitative analysis revealed that the concentration of RFRP-like substances was much higher in the brainstem and spinal cord than in other regions. Immunohistochemistry showed that RFRP-like immunoreactive perikarya were localized in the dorsomedial hypothalamic nucleus, the lateral superior olive, and the nucleus of the solitary tract. The dense networks of immunoreactive fibers were found in the lateral parabrachial nucleus, the lateral reticular nucleus, and the superficial layer of spinal trigeminal nucleus and dorsal horn of the spinal cord. Thus, RFRPs may participate not only in neuroendocrine functions but also in behavioral, sensory, and autonomic functions.

本文言語English
ページ(範囲)153-156
ページ数4
ジャーナルNeuroscience Letters
300
3
DOI
出版ステータスPublished - 2001 3月 16
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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