抄録
Neutrophil functions, including chemotaxis, reactive oxygen species (ROS)-producing capacity of neutrophils, and serum opsonic activity were investigated in 9 young healthy male volunteers. Venous blood of these volunteers was obtained under standardized conditions at 4-h intervals over a 24-h span. Neutrophil chemotaxis was evaluated by a modified Boyden technique, ROS-producing capacity of neutrophils and serum opsonic activity were measured by a simultaneous multiple measurement system based on luminol-dependent chemiluminescence and indicated by peak height and peak time. ROS-producing capacity of neutrophils and serum opsonic activity were activated in the daytime, and decreased from night to morning. There were negative correlations between the peak time of the luminol-dependent chemiluminescent response, neutrophil number (p<0.01) and segmented neutrophil number (p<0.01). On the other hand, no significant correlations were noted between serum opsonic activity and IgG, IgA, IgM, C3 or C4. In contrast, the peaks of neutrophil chemotaxis were at the wake-up time (6:00a.m.) and in the evening (6:00p.m.). This study indicates that diurnal variation of neutrophil function exists.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 65-70 |
| ページ数 | 6 |
| ジャーナル | Environmental Health and Preventive Medicine |
| 巻 | 1 |
| 発行部数 | 2 |
| 出版物ステータス | Published - 1996 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Pollution
- Public Health, Environmental and Occupational Health
これを引用
Diurnal Variation in Neutrophil Function. / Shiraishi, Masahiko; Suzuki, Katsuhiko; Abe, Tatsuya; Kikuchi, Takashi; Satoh, Hideki; Nakaji, Shigeyuki; Sugawara, Kazuo.
：: Environmental Health and Preventive Medicine, 巻 1, 番号 2, 1996, p. 65-70.研究成果: Article
}
TY - JOUR
T1 - Diurnal Variation in Neutrophil Function
AU - Shiraishi, Masahiko
AU - Suzuki, Katsuhiko
AU - Abe, Tatsuya
AU - Kikuchi, Takashi
AU - Satoh, Hideki
AU - Nakaji, Shigeyuki
AU - Sugawara, Kazuo
PY - 1996
Y1 - 1996
N2 - Neutrophil functions, including chemotaxis, reactive oxygen species (ROS)-producing capacity of neutrophils, and serum opsonic activity were investigated in 9 young healthy male volunteers. Venous blood of these volunteers was obtained under standardized conditions at 4-h intervals over a 24-h span. Neutrophil chemotaxis was evaluated by a modified Boyden technique, ROS-producing capacity of neutrophils and serum opsonic activity were measured by a simultaneous multiple measurement system based on luminol-dependent chemiluminescence and indicated by peak height and peak time. ROS-producing capacity of neutrophils and serum opsonic activity were activated in the daytime, and decreased from night to morning. There were negative correlations between the peak time of the luminol-dependent chemiluminescent response, neutrophil number (p<0.01) and segmented neutrophil number (p<0.01). On the other hand, no significant correlations were noted between serum opsonic activity and IgG, IgA, IgM, C3 or C4. In contrast, the peaks of neutrophil chemotaxis were at the wake-up time (6:00a.m.) and in the evening (6:00p.m.). This study indicates that diurnal variation of neutrophil function exists.
AB - Neutrophil functions, including chemotaxis, reactive oxygen species (ROS)-producing capacity of neutrophils, and serum opsonic activity were investigated in 9 young healthy male volunteers. Venous blood of these volunteers was obtained under standardized conditions at 4-h intervals over a 24-h span. Neutrophil chemotaxis was evaluated by a modified Boyden technique, ROS-producing capacity of neutrophils and serum opsonic activity were measured by a simultaneous multiple measurement system based on luminol-dependent chemiluminescence and indicated by peak height and peak time. ROS-producing capacity of neutrophils and serum opsonic activity were activated in the daytime, and decreased from night to morning. There were negative correlations between the peak time of the luminol-dependent chemiluminescent response, neutrophil number (p<0.01) and segmented neutrophil number (p<0.01). On the other hand, no significant correlations were noted between serum opsonic activity and IgG, IgA, IgM, C3 or C4. In contrast, the peaks of neutrophil chemotaxis were at the wake-up time (6:00a.m.) and in the evening (6:00p.m.). This study indicates that diurnal variation of neutrophil function exists.
KW - Diurnal variation
KW - Neutrophil chemotaxis
KW - Reactive oxygen species-producing capacity of human neutrophils
KW - Serum opsonic activity
UR - http://www.scopus.com/inward/record.url?scp=0345799906&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345799906&partnerID=8YFLogxK
M3 - Article
C2 - 21432424
AN - SCOPUS:0345799906
VL - 1
SP - 65
EP - 70
JO - Environmental Health and Preventive Medicine
JF - Environmental Health and Preventive Medicine
SN - 1342-078X
IS - 2
ER -