Dopamine D1 receptors and nonlinear probability weighting in risky choice

Hidehiko Takahashi*, Hiroshi Matsui, Colin Camerer, Harumasa Takano, Fumitoshi Kodaka, Takashi Ideno, Shigetaka Okubo, Kazuhisa Takemura, Ryosuke Arakawa, Yoko Eguchi, Toshiya Murai, Yoshiro Okubo, Motoichiro Kato, Hiroshi Ito, Tetsuya Suhara

*この研究の対応する著者

研究成果: Article査読

34 被引用数 (Scopus)

抄録

Misestimating risk could lead to disadvantaged choices such as initiation of drug use (or gambling) and transition to regular drug use (or gambling). Although the normative theory in decision-making under risks assumes that people typically take the probability-weighted expectation over possible utilities, experimental studies of choices among risks suggest that outcome probabilities are transformed nonlinearly into subjective decision weights by a nonlinear weighting function that overweights low probabilities and underweights high probabilities. Recent studies have revealed the neurocognitive mechanism of decision-making under risk. However, the role of modulatory neurotransmission in this process remains unclear. Using positron emission tomography, we directly investigated whether dopamine D1 and D2 receptors in the brain are associated with transformation of probabilities into decision weights in healthy volunteers. The binding of striatal D1 receptors is negatively correlated with the degree of nonlinearity of weighting function. Individuals with lower striatal D1 receptor density showed more pronounced overestimation of low probabilities and underestimation of high probabilities. This finding should contribute to a better understanding of the molecular mechanism of risky choice, and extreme or impaired decision-making observed in drug and gambling addiction.

本文言語English
ページ(範囲)16567-16572
ページ数6
ジャーナルJournal of Neuroscience
30
49
DOI
出版ステータスPublished - 2010 12月 8

ASJC Scopus subject areas

  • 神経科学(全般)

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