Early-life stress induces cognitive disorder in middle-aged mice

Hiroyuki Yajima, Asahi Haijima, Miski Aghnia Khairinisa, Noriaki Shimokawa, Izuki Amano, Yusuke Takatsuru*

*この研究の対応する著者

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Early-life stress can induce several neuropsychological disorders in adulthood. However, the underlying mechanisms inducing such disorders are still not fully understood. Furthermore, the effects of early-life stress on the changes in cognitive function with age are still not clarified. In this study, we used maternal deprivation (MD) to examine the cognitive function in middle-aged mice using a touchscreen-equipped operant chamber. In the visual-discrimination task, the aged (∼1.4 years old) control mice could accurately learn to discriminate between different visual stimuli. In contrast, the correct response rate of aged MD mice increased to ∼60% by day 10; it was still significantly lower than that of the control mice (85%). In the hippocampus of aged MD mice, the expression level of the N-methyl-d-aspartate receptor subunit GluN1 decreased significantly as compared to that in control mice. On the other hand, no significant difference in GluN1 expression level was detected in young (2.5 months old) mice. These findings indicate that early-life stress accelerates cognitive impairment in middle-aged mice.

本文言語English
ページ(範囲)139-146
ページ数8
ジャーナルNeurobiology of Aging
64
DOI
出版ステータスPublished - 2018 4月
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 加齢科学
  • 臨床神経学
  • 発生生物学
  • 老年医学

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