Early-life stress induces cognitive disorder in middle-aged mice

Hiroyuki Yajima, Asahi Haijima, Miski Aghnia Khairinisa, Noriaki Shimokawa, Izuki Amano, Yusuke Takatsuru

研究成果: Article

3 引用 (Scopus)

抄録

Early-life stress can induce several neuropsychological disorders in adulthood. However, the underlying mechanisms inducing such disorders are still not fully understood. Furthermore, the effects of early-life stress on the changes in cognitive function with age are still not clarified. In this study, we used maternal deprivation (MD) to examine the cognitive function in middle-aged mice using a touchscreen-equipped operant chamber. In the visual-discrimination task, the aged (∼1.4 years old) control mice could accurately learn to discriminate between different visual stimuli. In contrast, the correct response rate of aged MD mice increased to ∼60% by day 10; it was still significantly lower than that of the control mice (85%). In the hippocampus of aged MD mice, the expression level of the N-methyl-d-aspartate receptor subunit GluN1 decreased significantly as compared to that in control mice. On the other hand, no significant difference in GluN1 expression level was detected in young (2.5 months old) mice. These findings indicate that early-life stress accelerates cognitive impairment in middle-aged mice.

元の言語English
ページ(範囲)139-146
ページ数8
ジャーナルNeurobiology of Aging
64
DOI
出版物ステータスPublished - 2018 4
外部発表Yes

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Psychological Stress
Maternal Deprivation
Cognition
Hippocampus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

これを引用

Early-life stress induces cognitive disorder in middle-aged mice. / Yajima, Hiroyuki; Haijima, Asahi; Khairinisa, Miski Aghnia; Shimokawa, Noriaki; Amano, Izuki; Takatsuru, Yusuke.

:: Neurobiology of Aging, 巻 64, 04.2018, p. 139-146.

研究成果: Article

Yajima, Hiroyuki ; Haijima, Asahi ; Khairinisa, Miski Aghnia ; Shimokawa, Noriaki ; Amano, Izuki ; Takatsuru, Yusuke. / Early-life stress induces cognitive disorder in middle-aged mice. :: Neurobiology of Aging. 2018 ; 巻 64. pp. 139-146.
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AU - Amano, Izuki

AU - Takatsuru, Yusuke

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