Effect of 2-deoxy-d-glucose on the induction of tyrosinase in Coprinus macrorhizus

Hiroshi Nyunoya, Tatsuno Ishikawa

研究成果: Article

5 引用 (Scopus)

抄録

The addition of 2-deoxy-d-glucose and related glucose analogues to the cultures of Coprinus macrorhizus resulted in the induction of tyrosinase production and inhibition of fruiting body formation. The induction was inhibited by cycloheximide or high concentrations of glucose. Electrophoretic analyses revealed that tyrosinase, peroxidase, and tyrosinase inhibitors were present in crude mycelial extracts and that the production of an unusual tyrosinase isozyme was responsible for the enzyme induction.

元の言語English
ページ(範囲)229-238
ページ数10
ジャーナルThe Journal of General and Applied Microbiology
26
発行部数3
DOI
出版物ステータスPublished - 1980
外部発表Yes

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Coprinus
Monophenol Monooxygenase
Glucose
Enzyme Induction
Cycloheximide
Complex Mixtures
Peroxidase
Isoenzymes

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

これを引用

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abstract = "The addition of 2-deoxy-d-glucose and related glucose analogues to the cultures of Coprinus macrorhizus resulted in the induction of tyrosinase production and inhibition of fruiting body formation. The induction was inhibited by cycloheximide or high concentrations of glucose. Electrophoretic analyses revealed that tyrosinase, peroxidase, and tyrosinase inhibitors were present in crude mycelial extracts and that the production of an unusual tyrosinase isozyme was responsible for the enzyme induction.",
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AB - The addition of 2-deoxy-d-glucose and related glucose analogues to the cultures of Coprinus macrorhizus resulted in the induction of tyrosinase production and inhibition of fruiting body formation. The induction was inhibited by cycloheximide or high concentrations of glucose. Electrophoretic analyses revealed that tyrosinase, peroxidase, and tyrosinase inhibitors were present in crude mycelial extracts and that the production of an unusual tyrosinase isozyme was responsible for the enzyme induction.

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