Effect of a nitric oxide synthase inhibitor, N-nitro-l-arginine methylester, on light-induced phase delay of circadian rhythm of wheel-running activity in golden hamsters

Akihito Watanabe, Michiko Ono, Shigenobu Shibata, Shigenori Watanabe

研究成果: Article

36 引用 (Scopus)

抄録

Under constant darkness hamsters demonstrate free-running activity rhythms and light exposure during the early subjective night results in permanent phase delays of the activity rhythm. Recently, we reported that application of glutamate receptor agonists such as N-methyl-d-aspartate could reset the phase of the circadian rhythm of suprachiasmatic nucleus firing activity in vitro via nitric oxide production. In order to confirm this result by in vivo experiment, we examined the effect of nitric oxide synthesis inhibitor on the light-induced phase delay of circadian rhythms of wheel-running activity in hamsters. In vehicle-treated animals, light stimulation at circadian time 13.5 resulted in stable phase delays (1.3 ± 0.63 h), whereas pre-treatment with 150 mg/kg of N-nitro-l-arginine methylester (l-NAME) significantly attenuated light-induced phase delays (0.72 ± 0.18 h). l-NAME administration alone without light exposure, did not cause phase changes. The l-NAME-induced attenuating effect was reversed by co-administration of l-arginine (300 mg/kg). The present results suggest that nitric oxide production is involved in the light-induced phase delay of the hamster's circadian system.

元の言語English
ページ(範囲)25-28
ページ数4
ジャーナルNeuroscience Letters
192
発行部数1
DOI
出版物ステータスPublished - 1995 6 2
外部発表Yes

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Mesocricetus
Circadian Rhythm
Nitric Oxide Synthase
Running
Arginine
Light
Cricetinae
Nitric Oxide
Excitatory Amino Acid Agonists
Suprachiasmatic Nucleus
Darkness
Glutamate Receptors
Aspartic Acid

ASJC Scopus subject areas

  • Neuroscience(all)

これを引用

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abstract = "Under constant darkness hamsters demonstrate free-running activity rhythms and light exposure during the early subjective night results in permanent phase delays of the activity rhythm. Recently, we reported that application of glutamate receptor agonists such as N-methyl-d-aspartate could reset the phase of the circadian rhythm of suprachiasmatic nucleus firing activity in vitro via nitric oxide production. In order to confirm this result by in vivo experiment, we examined the effect of nitric oxide synthesis inhibitor on the light-induced phase delay of circadian rhythms of wheel-running activity in hamsters. In vehicle-treated animals, light stimulation at circadian time 13.5 resulted in stable phase delays (1.3 ± 0.63 h), whereas pre-treatment with 150 mg/kg of N-nitro-l-arginine methylester (l-NAME) significantly attenuated light-induced phase delays (0.72 ± 0.18 h). l-NAME administration alone without light exposure, did not cause phase changes. The l-NAME-induced attenuating effect was reversed by co-administration of l-arginine (300 mg/kg). The present results suggest that nitric oxide production is involved in the light-induced phase delay of the hamster's circadian system.",
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AU - Ono, Michiko

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

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N2 - Under constant darkness hamsters demonstrate free-running activity rhythms and light exposure during the early subjective night results in permanent phase delays of the activity rhythm. Recently, we reported that application of glutamate receptor agonists such as N-methyl-d-aspartate could reset the phase of the circadian rhythm of suprachiasmatic nucleus firing activity in vitro via nitric oxide production. In order to confirm this result by in vivo experiment, we examined the effect of nitric oxide synthesis inhibitor on the light-induced phase delay of circadian rhythms of wheel-running activity in hamsters. In vehicle-treated animals, light stimulation at circadian time 13.5 resulted in stable phase delays (1.3 ± 0.63 h), whereas pre-treatment with 150 mg/kg of N-nitro-l-arginine methylester (l-NAME) significantly attenuated light-induced phase delays (0.72 ± 0.18 h). l-NAME administration alone without light exposure, did not cause phase changes. The l-NAME-induced attenuating effect was reversed by co-administration of l-arginine (300 mg/kg). The present results suggest that nitric oxide production is involved in the light-induced phase delay of the hamster's circadian system.

AB - Under constant darkness hamsters demonstrate free-running activity rhythms and light exposure during the early subjective night results in permanent phase delays of the activity rhythm. Recently, we reported that application of glutamate receptor agonists such as N-methyl-d-aspartate could reset the phase of the circadian rhythm of suprachiasmatic nucleus firing activity in vitro via nitric oxide production. In order to confirm this result by in vivo experiment, we examined the effect of nitric oxide synthesis inhibitor on the light-induced phase delay of circadian rhythms of wheel-running activity in hamsters. In vehicle-treated animals, light stimulation at circadian time 13.5 resulted in stable phase delays (1.3 ± 0.63 h), whereas pre-treatment with 150 mg/kg of N-nitro-l-arginine methylester (l-NAME) significantly attenuated light-induced phase delays (0.72 ± 0.18 h). l-NAME administration alone without light exposure, did not cause phase changes. The l-NAME-induced attenuating effect was reversed by co-administration of l-arginine (300 mg/kg). The present results suggest that nitric oxide production is involved in the light-induced phase delay of the hamster's circadian system.

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KW - Suprachiasmatic nucleus

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