Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon

Zsolt Radák, Ryoya Takahashi, Atsushi Kumiyama, Hideko Nakamoto, Hideki Ohno, Tomomi Ookawara, Sataro Goto*

*この研究の対応する著者

研究成果: Article査読

77 被引用数 (Scopus)

抄録

Many studies have shown that lifelong dietary restriction (DR) can retard aging processes. Very few reports, however, are found that examined the effect of late onset DR on biochemical parameters in aging animals [Goto, S., Takahashi, R., Araki, S., Nakamoto, H., 2002b. Dietary restriction initiated in late adulthood can reverse age-related alterations of protein and protein metabolism. Ann. NY Acad. Sci. 959, 50-56]. We studied the effect of every-other-day feeding, initiated at the age of 26.5 months and continued for 3.5 months, on antioxidant enzymes, protein carbonyls, and proteasomes of the gastrocnemius muscle and tendon in rats. Age-related increase in the activity and content of Cu, Zn-SOD and the content of Mn-SOD was attenuated by the DR in both tissues. The same was true for glutathione peroxidase and catalase activities. Significant increase with age in protein reactive carbonyl derivatives (RCD) in the tendon was noted that was partially reversed by the DR. No significant change of RCD, however, was observed in the skeletal muscle. The age-related and DR-induced changes of the RCD in the tendon appeared to be associated with proteasome activity that decreases with age and increases by the DR. It is suggested that the late onset DR can have beneficial effects on the locomotive functions by reducing age-associated potentially detrimental oxidative protein damage in the tendon.

本文言語English
ページ(範囲)1423-1430
ページ数8
ジャーナルExperimental Gerontology
37
12
DOI
出版ステータスPublished - 2002 12月
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 加齢科学
  • 分子生物学
  • 遺伝学
  • 内分泌学
  • 細胞生物学

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