Effect Of Amino Acids and Monoamines on the Neuronal Activity of Suprachiasmatic Nucleus in Hypothalamic Slice Preparations

Shigenobu Shibata, Shyh Yuh Llou, Showa Ueki

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Influences of amino acids and monoamines on the single unit discharges of the suprachiasmatic nucleus (SCN) were investigated using hypothalamic slice preparations. lontophoretic application of GABA inhibited 90% and taurine inhibited 40% of SCN neurons, while glycine inhibited only 4%. L-glutamate excited about 50% of the neurons. Serotonin, noradrenaline and dopamine inhibited 30,22 and 26% of the SCN neurons, respectively. Amino acid effects were observed equally in both the ventrolateral part of the SCN and the remaining part of it, while monoamine effects were observed preferentially in the ventrolateral part of the SCN where the optic fibers and serotonin nerves terminated. These results suggest that amino acids and monoamines modulate the neuronal activity of the SCN through their direct effects.

本文言語English
ページ(範囲)1225-1231
ページ数7
ジャーナルThe Japanese Journal of Pharmacology
33
6
DOI
出版ステータスPublished - 1983
外部発表はい

ASJC Scopus subject areas

  • Pharmacology

フィンガープリント 「Effect Of Amino Acids and Monoamines on the Neuronal Activity of Suprachiasmatic Nucleus in Hypothalamic Slice Preparations」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル