Effect of cyclic stretch on tissue maturation in myoblast-laden hydrogel fibers

Shinako Bansai, Takashi Morikura, Hiroaki Onoe, Shogo Miyata*

*この研究の対応する著者

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Engineering of the skeletal muscles has attracted attention for the restoration of damaged muscles from myopathy, injury, and extraction of malignant tumors. Reconstructing a three-dimensional muscle using living cells could be a promising approach. However, the regenerated tissue exhibits a weak construction force due to the insufficient tissue maturation. The purpose of this study is to establish the reconstruction system for the skeletal muscle. We used a cell-laden core-shell hydrogel microfiber as a three-dimensional culture to control the cellular orientation. Moreover, to mature the muscle tissue in the microfiber, we also developed a custom-made culture device for imposing cyclic stretch stimulation using a motorized stage and the fiber-grab system. As a result, the directions of the myotubes were oriented and the mature myotubes could be formed by cyclic stretch stimulation.

本文言語English
論文番号399
ジャーナルMicromachines
10
6
DOI
出版ステータスPublished - 2019 6月 1
外部発表はい

ASJC Scopus subject areas

  • 制御およびシステム工学
  • 機械工学
  • 電子工学および電気工学

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