Effect of day-to-day variations in adrenal cortex hormone levels on abdominal symptoms

Nagisa Sugaya, Shuhei Izawa, Namiko Ogawa, Kentaro Shirotsuki, Hitomi Kobayashi, Kosuke C. Yamada, Hideki Tsumura, Shinobu Nomura, Hironori Shimada

    研究成果: Article

    4 引用 (Scopus)

    抄録

    Introduction: The hypothalamic-pituitary-adrenal axis is known to be related to abdominal symptoms, and the relationship between abdominal pain and cortisol secretory patterns has been previously investigated using a cross-sectional approach. Here, we investigated the effect of day-to-day variations in salivary cortisol and dehydroepiandrosterone-sulfate levels on abdominal symptoms in healthy individuals.Methods: Eleven college students (4 males and 7 females) participated in this study. The participants were asked to collect their saliva immediately after awakening and before bedtime for eight consecutive days. They also completed a questionnaire about abdominal symptoms before bedtime. The linear mixed model was applied to analyze the effects of the day-by-day variability or the 8-day average adrenal hormone level (at awakening, before bedtime, slope from awakening to bedtime) on abdominal symptoms.Results: The day-to-day variability of cortisol levels before bedtime was negatively related with loose stool, while the day-to-day variability of the cortisol slope was positively correlated with loose stool. A low 8-day average dehydroepiandrosterone-sulfate level at awakening was positively related with frequent bowel movements, loose stool, and long bouts of severe abdominal pain. Likewise, a low 8-day average dehydroepiandrosterone-sulfate slope was positively related with long bouts of abdominal pain.Conclusions: Low cortisol levels before bedtime and a steeper diurnal cortisol slope during the day may be related to bouts of diarrhea during the day.

    元の言語English
    記事番号2
    ジャーナルBioPsychoSocial Medicine
    4
    DOI
    出版物ステータスPublished - 2010 3 18

    Fingerprint

    Hydrocortisone
    Adrenal Cortex Hormones
    Dehydroepiandrosterone Sulfate
    Abdominal Pain
    Saliva
    Diarrhea
    Linear Models
    Hormones
    Students

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry
    • Psychology(all)
    • Social Psychology

    これを引用

    Effect of day-to-day variations in adrenal cortex hormone levels on abdominal symptoms. / Sugaya, Nagisa; Izawa, Shuhei; Ogawa, Namiko; Shirotsuki, Kentaro; Kobayashi, Hitomi; Yamada, Kosuke C.; Tsumura, Hideki; Nomura, Shinobu; Shimada, Hironori.

    :: BioPsychoSocial Medicine, 巻 4, 2, 18.03.2010.

    研究成果: Article

    Sugaya, N, Izawa, S, Ogawa, N, Shirotsuki, K, Kobayashi, H, Yamada, KC, Tsumura, H, Nomura, S & Shimada, H 2010, 'Effect of day-to-day variations in adrenal cortex hormone levels on abdominal symptoms', BioPsychoSocial Medicine, 巻. 4, 2. https://doi.org/10.1186/1751-0759-4-2
    Sugaya, Nagisa ; Izawa, Shuhei ; Ogawa, Namiko ; Shirotsuki, Kentaro ; Kobayashi, Hitomi ; Yamada, Kosuke C. ; Tsumura, Hideki ; Nomura, Shinobu ; Shimada, Hironori. / Effect of day-to-day variations in adrenal cortex hormone levels on abdominal symptoms. :: BioPsychoSocial Medicine. 2010 ; 巻 4.
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    abstract = "Introduction: The hypothalamic-pituitary-adrenal axis is known to be related to abdominal symptoms, and the relationship between abdominal pain and cortisol secretory patterns has been previously investigated using a cross-sectional approach. Here, we investigated the effect of day-to-day variations in salivary cortisol and dehydroepiandrosterone-sulfate levels on abdominal symptoms in healthy individuals.Methods: Eleven college students (4 males and 7 females) participated in this study. The participants were asked to collect their saliva immediately after awakening and before bedtime for eight consecutive days. They also completed a questionnaire about abdominal symptoms before bedtime. The linear mixed model was applied to analyze the effects of the day-by-day variability or the 8-day average adrenal hormone level (at awakening, before bedtime, slope from awakening to bedtime) on abdominal symptoms.Results: The day-to-day variability of cortisol levels before bedtime was negatively related with loose stool, while the day-to-day variability of the cortisol slope was positively correlated with loose stool. A low 8-day average dehydroepiandrosterone-sulfate level at awakening was positively related with frequent bowel movements, loose stool, and long bouts of severe abdominal pain. Likewise, a low 8-day average dehydroepiandrosterone-sulfate slope was positively related with long bouts of abdominal pain.Conclusions: Low cortisol levels before bedtime and a steeper diurnal cortisol slope during the day may be related to bouts of diarrhea during the day.",
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    AU - Ogawa, Namiko

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    AU - Kobayashi, Hitomi

    AU - Yamada, Kosuke C.

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    AU - Nomura, Shinobu

    AU - Shimada, Hironori

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