TY - JOUR
T1 - Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line
AU - Noguchi, Sumio
AU - Kubota, Yoshinobu
AU - Shuin, Taro
AU - Ito, Etsuro
AU - Inoue, Hiroko
AU - Yoshioka, Tohru
N1 - Funding Information:
This work was supported by Grant-in-Aids (63570753 Ministry of Education, Science and Culture of Japan.
PY - 1992/1/31
Y1 - 1992/1/31
N2 - Effect of exogenously added soybean phosphatidylinositol on c-myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c-myc unexpressed cells was reduced, while that of c-myc expressed cells was not. Death of c-myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca2+, and it seemed to be related to reduction of protein kinase C activity.
AB - Effect of exogenously added soybean phosphatidylinositol on c-myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c-myc unexpressed cells was reduced, while that of c-myc expressed cells was not. Death of c-myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca2+, and it seemed to be related to reduction of protein kinase C activity.
UR - http://www.scopus.com/inward/record.url?scp=0026501654&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026501654&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(92)91781-K
DO - 10.1016/0006-291X(92)91781-K
M3 - Article
C2 - 1734875
AN - SCOPUS:0026501654
SN - 0006-291X
VL - 182
SP - 644
EP - 650
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -
