Effect of free-living daily physical activity on salivary secretory IgA in elderly

Kazuhiro Shimizu, Fuminori Kimura, Takayuki Akimoto, Takao Akama, Shinya Kuno, Ichiro Kono

研究成果: Article査読

31 被引用数 (Scopus)

抄録

PURPOSE: The aim of this work was to assess the relationship in elderly subjects between free-living daily physical activity and mucosal immunity, especially salivary secretory immunoglobulin A (SIgA). METHODS: Elderly volunteers (114 men and 170 women) aged 71.3 ± 0.3 yr (range: 65-86 yr) participated in this study. Resting saliva samples were collected in the morning. Saliva samples stimulated by chewing a sterile cotton ball at a frequency of 60/60 s were collected. The SIgA concentration was measured using enzyme-linked immunosorbent assay (ELISA), and the SIgA secretion rate was calculated. Free-living step count (steps per day), energy expenditure (kJ·kg·d), and activity durations (min·d) at specific intensity levels (inactive, light, moderate, and vigorous) were evaluated using an electric pedometer. The data obtained were stratified by pedometer-determined steps per day using quartiles (Q1-Q4) for distribution. RESULTS: Elderly in quartiles showed step counts of 2962 ± 94, 5118 ± 62, 6832 ± 59, and 9951 ± 264 steps per day. Significant differences were found in the mean step count (P < 0.0001), energy expenditure (P < 0.0001), and activity duration (P < 0.0001) with increasing pedometer-determined activity quartiles. Both SIgA concentration and SIgA-secretion rate were significantly higher for Q3 than for Q1 (P < 0.05). Meanwhile, saliva flow rates showed no significant differences across quartiles. CONCLUSION: These results suggest that a free-living daily physical activity level of approximately 7000 steps per day might be regarded as a moderate daily physical activity target for elderly people to improve mucosal immune function.

本文言語English
ページ(範囲)593-598
ページ数6
ジャーナルMedicine and Science in Sports and Exercise
39
4
DOI
出版ステータスPublished - 2007 4

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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