Effect of gonadotropin releasing hormone on thermoregulatory vasomotor activity in ovariectomized female rats

Takayoshi Hosono, Motoko Yanase-Fujiwara, Yi Hong Zhang, Chen Xiao-ming, Yutaka Fukuda, Yasushi Asaki, Kenji Yamaji, Kazuyuki Kanosue

研究成果: Article

11 引用 (Scopus)

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To investigate the effect of gonadotropin releasing hormone (GnRH) on thermoregulatory skin vasomotion, we injected GnRH into various brain regions in both anesthetized and unanesthetized ovariectomized female rats. Local warming of preoptic area (PO) elicited skin vasodilation in anesthetized rats. Injection of 2 μg GnRH into the septal area lowered the threshold hypothalamic temperature for skin vasodilation at least for 2 h. Similar injections of 2 μg GnRH into the lateral ventricle (LV) and PO were ineffective. Although this vasodilative effect was also obtained after the injection of 20 ng GnRH into the septal area, injections of 2 ng GnRH were without effect. Not only injections of 20 ng Antide, a potent GnRH antagonist, but also injections of the mixed solution of 20 ng GnRH and 20 ng Antide were also without effect. In unanesthetized and unrestrained rats at an ambient temperature of 17°C, injections of 20 ng GnRH into the septal area elicited tail vasodilation lasting for 30 minutes, whereas vehicle injections were ineffective. Injections of 20 ng GnRH into LV and PO were also ineffective. These results indicate that GnRH can elicit thermoregulatory skin vasomotion by acting on GnRH receptors in the septal area. This thermoregulatory vasodilative effect of GnRH might be possibly related to the etiology of climacteric hot flush.

元の言語English
ページ(範囲)88-94
ページ数7
ジャーナルBrain Research
754
発行部数1-2
DOI
出版物ステータスPublished - 1997 4 18

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Hosono, T., Yanase-Fujiwara, M., Zhang, Y. H., Xiao-ming, C., Fukuda, Y., Asaki, Y., Yamaji, K., & Kanosue, K. (1997). Effect of gonadotropin releasing hormone on thermoregulatory vasomotor activity in ovariectomized female rats. Brain Research, 754(1-2), 88-94. https://doi.org/10.1016/S0006-8993(97)00060-7