Effect of magnetite nanoparticles on living rate of MCF-7 human breast cancer cells

Daisuke Baba, Yasuhiro Seiko, Takuya Nakanishi, Hong Zhang, Atsushi Arakaki, Tadashi Matsunaga, Tetsuya Osaka

研究成果: Article

30 引用 (Scopus)

抜粋

Superparamagnetic and ferromagnetic magnetite nanoparticles, with diameters of approximately 13 and 44. nm, respectively, were synthesized and their uptake amount and heating efficiency were evaluated for application to magnetic hyperthermia. Both nanoparticles had almost the same zeta-potential (+10.2. mV) and hydrodynamic size (~1μm) and there was no significant difference in their uptake amount 18. h after they were added to the medium. After internalization, the ferromagnetic nanoparticles incorporated in human breast cancer cells (MCF-7) showed a higher heating efficiency than the superparamagnetic nanoparticles when an external magnetic field (4. kW, 250. kHz) high enough to produce heat by hysteresis loss was applied, followed by cellular death of MCF-7 with high ferromagnetic nanoparticle content.

元の言語English
ページ(範囲)254-257
ページ数4
ジャーナルColloids and Surfaces B: Biointerfaces
95
DOI
出版物ステータスPublished - 2012 6 15

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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