Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia

Hiromichi Akahori*, Kazunori Shibuya, Masako Obuchi, Yoshito Nishizawa, Akio Tsuji, Koji Kabaya, Masaru Kusaka, Hideya Ohashi, Haruhiko Tsumura, Takashi Kato, Hiroshi Miyazaki

*この研究の対応する著者

研究成果: Article査読

50 被引用数 (Scopus)

抄録

We examined the effects of recombinant human thrombopoietin (rhTPO) on myelosuppressive chemotherapy-induced thrombocytopenia in cynomolgus monkeys. After treatment with nimustine (ACNU) on day 0, the monkeys intravenously received rhTPO at a dose of 0.04, 0.2 or 1 μg/kg/d or monkey's serum once each day from day 1 to day 2.8. Administration of rhTPO reduced the severity of thrombocytopenia and accelerated the rate of platelet recovery in a dose-dependent fashion. Treatment with the highest rhTPO dose completely prevented thrombocytopenia and stimulated a marked increase in platelet counts over the normal values. Animals treated with ACNU also became neutropenic and slightly anaemic. Administration of rhTPO following ACNU treatment significantly improved neutropenia with increasing doses of rhTPO, but had no effect on anaemia. Compared to the control animals, rhTP0-treated animals exhibited no significant-changes in several serum parameters, C-reactive protein concentration and some blood coagulation profiles within the study period. These results suggest a therapeutic efficacy of rhTPO in improving chemotherapy-induced thrombocytopenia.

本文言語English
ページ(範囲)722-728
ページ数7
ジャーナルBritish Journal of Haematology
94
4
DOI
出版ステータスPublished - 1996 1月 1
外部発表はい

ASJC Scopus subject areas

  • 血液学

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