Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia

Hiromichi Akahori, Kazunori Shibuya, Masako Obuchi, Yoshito Nishizawa, Akio Tsuji, Koji Kabaya, Masaru Kusaka, Hideya Ohashi, Haruhiko Tsumura, Takashi Kato, Hiroshi Miyazaki

研究成果: Article

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We examined the effects of recombinant human thrombopoietin (rhTPO) on myelosuppressive chemotherapy-induced thrombocytopenia in cynomolgus monkeys. After treatment with nimustine (ACNU) on day 0, the monkeys intravenously received rhTPO at a dose of 0.04, 0.2 or 1 μg/kg/d or monkey's serum once each day from day 1 to day 2.8. Administration of rhTPO reduced the severity of thrombocytopenia and accelerated the rate of platelet recovery in a dose-dependent fashion. Treatment with the highest rhTPO dose completely prevented thrombocytopenia and stimulated a marked increase in platelet counts over the normal values. Animals treated with ACNU also became neutropenic and slightly anaemic. Administration of rhTPO following ACNU treatment significantly improved neutropenia with increasing doses of rhTPO, but had no effect on anaemia. Compared to the control animals, rhTP0-treated animals exhibited no significant-changes in several serum parameters, C-reactive protein concentration and some blood coagulation profiles within the study period. These results suggest a therapeutic efficacy of rhTPO in improving chemotherapy-induced thrombocytopenia.

元の言語English
ページ(範囲)722-728
ページ数7
ジャーナルBritish Journal of Haematology
94
発行部数4
DOI
出版物ステータスPublished - 1996 1 1
外部発表Yes

ASJC Scopus subject areas

  • Hematology

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    Akahori, H., Shibuya, K., Obuchi, M., Nishizawa, Y., Tsuji, A., Kabaya, K., Kusaka, M., Ohashi, H., Tsumura, H., Kato, T., & Miyazaki, H. (1996). Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia. British Journal of Haematology, 94(4), 722-728. https://doi.org/10.1046/j.1365-2141.1996.d01-1842.x